Seminars in Pediatric Surgery
Volume 16, Issue 2 , Pages 94-100 , May 2007

Diaphragm development and congenital diaphragmatic hernia

  • Robin D. Clugston
    • ,
  • John J. Greer, PhD

      Affiliations

    • Corresponding Author InformationAddress reprint requests and correspondence: John J. Greer, PhD, University of Alberta, Department of Physiology, 513 HMRC, Centre for Neuroscience Edmonton, AB, Canada T6G 2S2.

References 

  1. Greer JJ, Babiuk RP, Thebaud B. Etiology of congenital diaphragmatic hernia: the retinoid hypothesis. Pediatr Res. 2003;53:726–730
  2. Slavotinek AM. The genetics of congenital diaphragmatic hernia. Semin Perinatol. 2005;29:77–85
  3. Dunwoodie SL, Rodriguez TA, Beddington RSP. Msg1 and Mrg1, founding members of a gene family, show distinct patterns of gene expression during mouse embryogenesis. Mech Dev. 1998;72:27–40
  4. Wells LJ. Development of the human diaphragm and pleural sacs. Contrib Embryol. 1954;35:107–134
  5. Kluth D, Petersen C, Zimmerman HJ. The developmental anatomy of congenital diaphragmatic hernia. Pediatr Surg Int. 1987;2:322–326
  6. Kluth D, Keijzer R, Hertl M, et al. Embryology of congenital diaphragmatic hernia. Semin Pediatr Surg. 1996;5(4):224–233
  7. Babiuk RP, Zhang W, Clugston R, et al. Embryological origins and development of the rat diaphragm. J Comp Neurol. 2003;455:477–487
  8. Skandalakis JE, Gray SW, Ricketts RR. The diaphragm. In:  Skandalakis JE,  Gray SW editor. Embryology for Surgeons (chapter 15). Baltimore, MD: Williams and Wilkins; 1994;p. 491–539
  9. Robertson DJ, Harmon CM, Goldberg S. Right congenital diaphragmatic hernia associated with fusion of the liver and lung. J Pediatr Surg. 2006;41:e9–e10
  10. Bladt F, Riethmacher D, Isenmann C, et al. Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb. Nature. 1995;376:768–771
  11. Birchmeier C, Brohman H. Genes that control the development of migrating muscle precursor cell. Curr Opin Cell Biol. 2000;12:725–730
  12. Gross MK, Moran-Rivard L, Velasquez T, et al. Lbx1 is required for muscle precursor migration along a lateral pathway into the limb. Development. 2000;127:413–424
  13. Greer JJ, Allan DW, Martin-Caraballo M, et al. Invited review: an overview of phrenic nerve and diaphragm muscle development in the perinatal rat. J Appl Physiol. 1999;86:779–786
  14. Kobayashi K, Lemke RP, Greer JJ. Development of fetal breathing movements in the rat. J Appl Physiol. 2001;91:316–320
  15. Torfs CP, Curry CJ, Bateson TF, et al. A population-based study of congenital diaphragmatic hernia. Teratology. 1992;46:555–565
  16. Yang W, Carmichael SL, Harris JA, et al. Epidemiologic characteristics of congenital diaphragmatic hernia among 2.5 million Californian births, 1989-1997. Birth Defects Res A Clin Mol Teratol. 2006;76:170–174
  17. Valls-i-Soler A, Alfonso LF, Arnaiz A, et al. Pulmonary surfactant dysfunction in congenital diaphragmatic hernia: experimental and clinical findings. Biol Neonate. 1996;69:318–326
  18. Thebaud B, Mercier JC, Dinh-Xuan AT. Congenital diaphragmatic hernia (A cause of persistent pulmonary hypertension of the newborn which lacks an effective therapy). Biol Neonate. 1998;74:323–336
  19. Guilbert TW, Gebb SA, Shannon JM. Lung hypoplasia in the nitrofen model of congenital diaphragmatic hernia occurs early in development. Am J Physiol Lung Cell Mol Physiol. 2000;279:L1159–L1171
  20. Keijzer R, Liu J, Deimling J, et al. Dual-hit hypothesis explains pulmonary hypoplasia in the nitrofen model of congenital diaphragmatic hernia. Am J Pathol. 2000;156:1299–1306
  21. Chinoy M. Pulmonary hypoplasia and congenital diaphragmatic hernia: advances in the pathogenetics and regulation of lung development. J Surg Res. 2002;106:209–223
  22. Smith NP, Jesudason EC, Losty PD. Congenital diaphragmatic hernia. Paediatr Respir Rev. 2002;3:339–348
  23. Ambrose AM, Larson PS, Borzelleca JF, et al. Toxicologic studies on 2,4-dichlorophenyl-p-nitrophenyl ether. Toxicol Appl Pharmacol. 1997;19:263–275
  24. Costlow RD, Manson JM. The heart and diaphragm: target organs in the neonatal death induced by nitrofen (2,4-dichlorophenyl-p-nitrophenyl ether). Toxicology. 1981;20:209–227
  25. Allan DW, Greer JJ. Pathogenesis of nitrofen-induced congenital diaphragmatic hernia in fetal rats. J Appl Physiol. 1997;83:338–347
  26. Cilley RE, Zgleszewski SE, Krummel TM, et al. Nitrofen dose-dependent gestational day-specific murine lung hypoplasia and left-sided diaphragmatic hernia. Am J Physiol. 1997;272:L362–L371
  27. Mey J, Babiuk RP, Clugston R, et al. Retinal dehydrogenase-2 is inhibited by compounds that induce congenital diaphragmatic hernias in rodents. Am J Pathol. 2003;162:673–679
  28. Babiuk RP, Greer JJ. Diaphragm defects occur in a congenital diaphragmatic hernia model independent of myogenesis and lung formation. Am J Physiol Lung Cell Mol Physiol. 2002;283:L1310–L1314
  29. Iritani I. Experimental study on embryogenesis of congenital diaphragmatic hernia. Anat Embryol. 1984;169:133–139
  30. Sekine K, Ohuchi H, Fujiwara M, et al. Fgf10 is essential for limb and lung bud formation. Nat Genet. 1999;21:138–141
  31. Arkovitz MS, Hyatt BA, Shannon JM. Lung development is not necessary for diaphragm development in mice. J Pediatr Surg. 2005;40:1390–1394
  32. Podlech J, Richter J, Czygan P, et al. Bilateral agenesis/aplasia of the lungs: report of a second case in the offspring of one woman. Pediatr Pathol Lab Med. 1995;15:781–790
  33. Gabarre JA, Galindo Izquierdo A, Rasero Ponferrada M, et al. Isolated unilateral pulmonary agenesis: early prenatal diagnosis and long-term follow up. J Ultrasound Med. 2005;24:865–868
  34. Sharma S, Kumar S, Yaduvanshi D, et al. Isolated unilateral pulmonary agenesis. Indian Pediatr. 2005;42:170–172
  35. Clugston RD, Klattig J, Englert C, et al. Teratogen induced, dietary and genetic models of congenital diaphragmatic hernia share a common mechanism of pathogenesis. Am J Pathol. 2006;169:1541–1549
  36. You LR, Takamoto N, Yu CT, et al. Mouse lacking COUP-TFII as an animal model of Bochdalek-type congenital diaphragmatic hernia. Proc Natl Acad Sci U S A. 2005;102:16351–16356
  37. Wells LJ. In: Development of the human diaphragm and pleural sacs (Contributions to Embryology). 231:Carnegie Institution of Washington; 1954;p. 107–134Pub. No. 603.
  38. Ackerman KG, Herron BJ, Vargas SO, et al. Fog2 is required for normal diaphragm and lung development in mice and humans. PLoS Genet. 2005;1:58–65
  39. Yuan W, Rao Y, Babiuk RP, et al. A genetic model for a central (septum transversum) congenital diaphragmatic hernia in mice lacking slit3. Proc Natl Acad Sci U S A. 2003;100:5217–5222
  40. Liu J, Zhang L, Wang D, et al. Congenital diaphragmatic hernia, kidney agenesis and cardiac defects associated with slit-3 deficiency in mice. Mech Dev. 2003;120:1059–1070
  41. Honore LH, Torfs CP, Curry CJ. Possible association between the hernia of Morgagni and trisomy 21. Am J Med Genet. 1993;47:255–256
  42. Bush M, Beck BB, Dietz J, et al. Radiographic evaluation of diaphragmatic defects in golden lion tamarins (Leontopithecus rosalia rosalia): implications for reintroduction. 1996;27:346–357
  43. Randolph J, Bush M, Abramowitz M, et al. Surgical correction of familial diaphragmatic hernia of Morgagni in the Golden Lion Tamarin. J Pediatr Surg. 1981;16:396–401

PII: S1055-8586(07)00005-4

doi: 10.1053/j.sempedsurg.2007.01.004

Seminars in Pediatric Surgery
Volume 16, Issue 2 , Pages 94-100 , May 2007

Article Tools

* Image Usage & Resolution