Seminars in Pediatric Surgery
Volume 15, Issue 4 , Pages 284-292 , November 2006

Stem cells: Tissue regeneration and cancer

  • Monika Tataria, MD
    • ,
  • Scott V. Perryman, MD
    • ,
  • Karl G. Sylvester, MD

      Affiliations

    • Corresponding Author InformationAddress reprint requests and correspondence: Karl G. Sylvester, MD, Stanford University School of Medicine, Division of Pediatric Surgery, Department of Surgery, Lucille Packard Children’s Hospital, 257 Campus Drive, Stanford, CA 94305.

References 

  1. Wobus AM, Boheler KR. Embryonic stem cells: prospects for developmental biology and cell therapy. Physiol Rev. 2005;85(2):635–678
  2. Evans MJ, Kaufman MH. Establishment in culture of pluripotential cells from mouse embryos. Nature. 1981;292(5819):154–156
  3. Martin GR. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci USA. 1981;78(12):7634–7638
  4. Smith AG. Embryo-derived stem cells of mice and men. Annu Rev Cell Dev Biol. 2001;17:435–462
  5. Kleinsmith LJ, Pierce GB. Multipotentiality of single embryonal carcinoma cells. Cancer Res. 1964;24:1544–1551
  6. Martin GR, Evans MJ. Differentiation of clonal lines of teratocarcinoma cells: formation of embryoid bodies in vitro. Proc Natl Acad Sci USA. 1975;72(4):1441–1445
  7. Wilmut I, Schnieke AE, McWhir J, et al. Viable offspring derived from fetal and adult mammalian cells. Nature. 1997;385(6619):810–813
  8. Bianco P, Robey PG. Stem cells in tissue engineering. Nature. 2001;414(6859):118–121
  9. Devine SM. Mesenchymal stem cells: will they have a role in the clinic?. J Cell Biochem. 2002;38(suppl):73–79
  10. Lovell-Badge R. The future for stem cell research. Nature. 2001;414(6859):88–91
  11. Surani MA. Reprogramming of genome function through epigenetic inheritance. Nature. 2001;414(6859):122–128
  12. McLaren A. Ethical and social considerations of stem cell research. Nature. 2001;414(6859):129–131
  13. Weissman IL. Stem cells: scientific, medical, and political issues. N Engl J Med. 2002;346(20):1576–1579
  14. Donovan PJ, Gearhart J. The end of the beginning for pluripotent stem cells. Nature. 2001;414(6859):92–97
  15. Spradling A, Drummond-Barbosa D, Kai T. Stem cells find their niche. Nature. 2001;414(6859):98–104
  16. Thomson JA, Itskovitz-Eldor J, Shapiro SS, et al. Embryonic stem cell lines derived from human blastocysts. Science. 1998;282(5391):1145–1147
  17. Lanza RP, Chung HY, Yoo JJ, et al. Generation of histocompatible tissues using nuclear transplantation. Nat Biotechnol. 2002;20(7):689–696
  18. Drukker M, Katz G, Urbach A, et al. Characterization of the expression of MHC proteins in human embryonic stem cells. Proc Natl Acad Sci USA. 2002;99(15):9864–9869
  19. Rideout WM, Hochedlinger K, Kyba M, et al. Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy. Cell. 2002;109(1):17–27
  20. Cibelli JB, Campbell KH, Seidel GE, et al. The health profile of cloned animals. Nat Biotechnol. 2002;20(1):13–14
  21. Humpherys D, Eggan K, Akutsu H, et al. Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei. Proc Natl Acad Sci USA. 2002;99(20):12889–12894
  22. Jaenisch R, Bird A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet. 2003;33(suppl):245–254
  23. DeBaun MR, Niemitz EL, Feinberg AP. Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alternations of LIT1 and H19. Am J Hum Genet. 2003;72(1):156–160
  24. Maher ER, Brueton LA, Bowdin SC, et al. Beckwith-Wiedemann syndrome and assisted reproduction technology (ART). J Med Genet. 2003;40(1):62–64
  25. Reubinoff BE, Pera MF, Fong CY, et al. Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. Nat Biotechnol. 2000;18(4):399–404
  26. Levenberg S, Golub JS, Amit M, et al. Endothelial cells derived from human embryonic stem cells. Proc Natl Acad Sci USA. 2002;99(7):4391–4396
  27. Murray P, Edgar D. The regulation of embryonic stem cell differentiation by leukaemia inhibitory factor (LIF). Differentiation. 2001;68(4-5):227–234
  28. Roach ML, McNeish JD. Methods for the isolation and maintenance of murine embryonic stem cells. Methods Mol Biol. 2002;185:1–16
  29. Chambers I, Colby D, Robertson M, et al. : Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell. 2003;113(5):645–655
  30. Loh YH, Wu Q, Chew JL, et al. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet. 2006;38(4):431–440
  31. Mitsui K, Tokuzawa Y, Itoh H, et al. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell. 2003;113(5):631–642
  32. Bortvin A, Eggan K, Skaletsky H, et al. Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei. Development. 2003;130(8):1673–1680
  33. Lu J, Hou R, Booth CJ, et al. Defined culture conditions of human embryonic stem cells. Proc Natl Acad Sci USA. 2006;103(15):5688–5693
  34. Lajtha LG, Gilbert CW, Porteous DD, et al. Kinetics of a bone-marrow stem-cell population. Ann N Y Acad Sci. 1964;113:742–752
  35. Fuchs E, Tumbar T, Guasch G. Socializing with the neighbors: stem cells and their niche. Cell. 2004;116(6):769–778
  36. Osawa M, Hanada K, Hamada H, et al. Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science. 1996;273(5272):242–245
  37. Watt FM, Hogan BL. Out of Eden: stem cells and their niches. Science. 2000;287(5457):1427–1430
  38. Kondo M, Wagers AJ, Manz MG, et al. Biology of hematopoietic stem cells and progenitors: implications for clinical application. Annu Rev Immunol. 2003;21:759–806
  39. Ponder BA, Schmidt GH, Wilkinson MM, et al. Derivation of mouse intestinal crypts from single progenitor cells. Nature. 1985;313(6004):689–691
  40. Heath JP. Epithelial cell migration in the intestine. Cell Biol Int. 1996;20(2):139–146
  41. Bianco P, Riminucci M, Gronthos S, et al. Bone marrow stromal stem cells: nature, biology, and potential applications. Stem Cells. 2001;19(3):180–192
  42. Devine SM, Peter S, Martin BJ, et al. Mesenchymal stem cells: stealth and suppression. Cancer J. 2001;7(suppl 2):S76–S82
  43. Gerson SL. Mesenchymal stem cells: no longer second class marrow citizens. Nat Med. 1999;5(3):262–264
  44. Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science. 1999;284(5411):143–147
  45. Bosch P, Musgrave DS, Lee JY, et al. Osteoprogenitor cells within skeletal muscle. J Orthop Res. 2000;18(6):933–944
  46. Sarugaser R, Lickorish D, Baksh , et al. Human umbilical cord perivascular (HUCPV) cells: a source of mesenchymal progenitors. Stem Cells. 2005;23(2):220–229
  47. Song L, Young NJ, Webb NE, et al. Origin and characterization of multipotential mesenchymal stem cells derived from adult human trabecular bone. Stem Cells Dev. 2005;14(6):712–721
  48. Zuk PA, Zhu M, Ashjian P, et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell. 2002;13(12):4279–4295
  49. Michallet M, Thomas X, Vernant JP, et al. Long-term outcome after allogeneic hematopoietic stem cell transplantation for advanced stage acute myeloblastic leukemia: a retrospective study of 379 patients reported to the Societe Francaise de Greffe de Moelle (SFGM). Bone Marrow Transplant. 2000;26(11):1157–1163
  50. Negrin RS, Atkinson K, Leemhuis T, et al. Transplantation of highly purified CD34+Thy-1+ hematopoietic stem cells in patients with metastatic breast cancer. Biol Blood Marrow Transplant. 2000;6(3):262–271
  51. Vose JM, Zhang MJ, Rowlings PA, et al. Autologous transplantation for diffuse aggressive non-Hodgkin’s lymphoma in patients never achieving remission: a report from the Autologous Blood and Marrow Transplant Registry. J Clin Oncol. 2001;19(2):406–413
  52. Shizuru JA, Negrin RS, Weissman IL. Hematopoietic stem and progenitor cells: clinical and preclinical regeneration of the hematolymphoid system. Annu Rev Med. 2005;56:509–538
  53. Shizuru JA, Weissman IL, Kernoff R, et al. Purified hematopoietic stem cell grafts induce tolerance to alloantigens and can mediate positive and negative T cell selection. Proc Natl Acad Sci USA. 2000;97(17):9555–9560
  54. Ballas CB, Zielske SP, Gerson SL. Adult bone marrow stem cells for cell and gene therapies: implications for greater use. J Cell Biochem. 2002;38(suppl):20–28
  55. Bordignon C, Roncarolo MG. Therapeutic applications for hematopoietic stem cell gene transfer. Nat Immunol. 2002;3(4):318–321
  56. Lemoine NR. The power to deliver: stem cells in gene therapy. Gene Ther. 2002;9(10):603–605
  57. Horwitz EM, Prockop DJ, Gordon PL, et al. Clinical responses to bone marrow transplantation in children with severe osteogenesis imperfecta. Blood. 2001;97(5):1227–1231
  58. Prockop DJ. Targeting gene therapy for osteogenesis imperfecta. N Engl J Med. 2004;350(22):2302–2304
  59. Lagasse E, Shizuru JA, Uchida , et al. Toward regenerative medicine. Immunity. 2001;14(4):425–436
  60. Park KI, Ourednik J, Ourednik V, et al. Global gene and cell replacement strategies via stem cells. Gene Ther. 2002;9(10):613–624
  61. Eiselt P, Kim BS, Chacko B, et al. Development of technologies aiding large-tissue engineering. Biotechnol Prog. 1998;14(1):134–140
  62. Kim WS, Vacanti CA, Upton J, et al. Bone defect repair with tissue-engineered cartilage. Plast Reconstr Surg. 1994;94(5):580–584
  63. Ildstad ST, Sachs DH. Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts. Nature. 1984;307(5947):168–170
  64. Kaufman CL, Ildstad ST. Induction of donor-specific tolerance by transplantation of bone marrow. Ther Immunol. 1994;1(2):101–111
  65. Kleeberger W, Rothanel T, Glockner S, et al. High frequency of epithelial chimerism in liver transplants demonstrated by microdissection and STR-analysis. Hepatology. 2002;35(1):110–116
  66. Solter D. From teratocarcinomas to embryonic stem cells and beyond: a history of embryonic stem cell research. Nat Rev Genet. 2006;7(4):319–327
  67. Bosch FX, Ribes J, Cleries , et al. Epidemiology of hepatocellular carcinoma. Clin Liver Dis. 2005;9(2):191–211
  68. Billon N, Jolicoeur C, Ying QL, et al. Normal timing of oligodendrocyte development from genetically engineered, lineage-selectable mouse ES cells. J Cell Sci. 2002;115(Pt 18):3657–3665
  69. Wu X, Groves FD, McLaughlin CC, et al. Cancer incidence patterns among adolescents and young adults in the United States. Cancer Causes Control. 2005;16(3):309–320
  70. Ohtani N, Yamakoshi K, Takahashi A, et al. The p16INK4a-RB pathway: molecular link between cellular senescence and tumor suppression. J Med Invest. 2004;51(3-4):146–153
  71. Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med. 1997;3(7):730–737
  72. Singh SK, Clarke ID, Terasaki M, et al. Identification of a cancer stem cell in human brain tumors. Cancer Res. 2003;63(18):5821–5828
  73. Singh SK, Hawkins C, Clarke ID, et al. Identification of human brain tumor initiating cells. Nature. 2004;432(7015):396–401
  74. Cozzio A, Passegue E, Ayton PM, et al. Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors. Genes Dev. 2003;17(24):3029–3035
  75. Al-Hajj M, Wicha MS, Benito-Hernandez A, et al. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA. 2003;100(7):3983–3988
  76. Hamburger A, Salmon SE. Primary bioassay of human myeloma stem cells. J Clin Invest. 1977;60(4):846–854
  77. Hamburger AW, Salmon SE. Primary bioassay of human tumor stem cells. Science. 1977;197(4302):461–463
  78. Southam CM, Tanzi AF, Ross SL. Growth of primary explants of human cancer in newborn rats. Cancer. 1966;19(11):1670–1682
  79. Berman DM, Karhadkar SS, Hallahan AR, et al. Medulloblastoma growth inhibition by hedgehog pathway blockade. Science. 2002;297(5586):1559–1561
  80. de La Coste A, Romagnolo B, Billuart P, et al. Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas. Proc Natl Acad Sci USA. 1998;95(15):8847–8851
  81. Monga SP, Pediaditakis P, Mule K, et al. Changes in WNT/beta-catenin pathway during regulated growth in rat liver regeneration. Hepatology. 2001;33(5):1098–1109
  82. Niemann C, Unden AB, Lyle S, et al. Indian hedgehog and beta-catenin signaling: role in the sebaceous lineage of normal and neoplastic mammalian epidermis. Proc Natl Acad Sci USA. 2003;100(suppl 1):11873–11880
  83. van de Wetering M, Sancho E, Verweij C, et al. The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell. 2002;111(2):241–250
  84. van den Brink GR, Bleuming SA, Hardwick JC, et al. Indian hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation. Nat Genet. 2004;36(3):277–282
  85. Yau TO, Chan CY, Chan KL, et al. HDPR1, a novel inhibitor of the WNT/Beta-catenin signaling, is frequently downregulated in hepatocellular carcinoma involvement of methylation-mediated gene silencing. Oncogene. 2005;24(9):1607–1614
  86. Ha NC, Tonozuka T, Stamos JL, et al. Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation. Mol Cell. 2004;15(4):511–521
  87. Munemitsu S, Albert I, Souza B, et al. Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. Proc Natl Acad Sci USA. 1995;92(7):3046–3050
  88. Nhieu JT, Renard CA, Wei Y, et al. : Nuclear accumulation of mutated beta-catenin in hepatocellular carcinoma is associated with increased cell proliferation. Am J Pathol. 1999;155(3):703–710
  89. Shang XZ, Zhu H, Lin K, et al. Stabilized beta-catenin promotes hepatocyte proliferation and inhibits TNFalpha-induced apoptosis. Lab Invest. 2004;84(3):332–341
  90. Terskikh AV, Easterday MC, Li L, et al. From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs. Proc Natl Acad Sci USA. 2001;98(14):7934–7939
  91. Obana K, Yang HW, Piao HY, et al. Aberrations of P16INK4A, p14ARF and P15INK4B genes in pediatric solid tumors. Int J Oncol. 2003;23(4):1151–1157
  92. Koesters R, von Knebel Dueberitz M. The Wnt signaling pathway in solid childhood tumors. Cancer Lett. 2003;198(2):123–138
  93. Buendia MA. Genetics of hepatocellular carcinoma. Semin Cancer Biol. 2000;10(3):185–200

PII: S1055-8586(06)00056-4

doi: 10.1053/j.sempedsurg.2006.07.008

Seminars in Pediatric Surgery
Volume 15, Issue 4 , Pages 284-292 , November 2006

Article Tools

* Image Usage & Resolution