Seminars in Pediatric Surgery
Volume 15, Issue 4 , Pages 259-266 , November 2006

Molecular imaging and radioimmunoguided surgery

  • Carlos M. Mery, MD, MPH

      Affiliations

    • Biodesign Surgical Innovation Program, Stanford University, Stanford, California
    • Brigham & Women’s Hospital, Boston, Massachusetts
    • Corresponding Author InformationAddress reprint requests and correspondence: Carlos M. Mery, MD, MPH, Stanford Biodesign Surgical Innovation Program, James H. Clark Center, 318 Campus Drive, Rm E100, Stanford, CA 94305-5428.
    • ,
  • Bilal M. Shafi, MD, MSE

      Affiliations

    • Biodesign Surgical Innovation Program, Stanford University, Stanford, California
    • University of Pennsylvania, Philadelphia, Pennsylvania.
    • ,
  • Gary Binyamin, PhD

      Affiliations

    • Biodesign Surgical Innovation Program, Stanford University, Stanford, California

References 

  1. Kohler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature. 1975;256:495–497
  2. Parslow TG. Immunoglobulins and immunoglobulin genes. In:  Parslow TG,  Stites DP,  Terr AI, et al. editor. Medical Immunology. New York, NY: McGraw Hill; 2001;
  3. Nieroda CA, Milenic DE, Colcher D, et al. Monoclonal antibodies for use in radioimmunoguided surgery (RIGS). In:  Martin EW editors. Radioimmunoguided Surgery (RIGS) in the Detection and Treatment of Colorectal Cancer. Austin, TX: R.G. Landes Company; 1994;
  4. Goel A, Batra SK. Antibody constructs for radioimmunodiagnosis and treatment of human pancreatic cancer. Teratog Carcinog Mutagen. 2001;21:45–57
  5. Van de Wiele C, Revets H, Mertens N. Radioimmunoimaging (Advances and prospects). Q J Nucl Med Mol Imaging. 2004;48:317–325
  6. Sergides IG, Austin RC, Winslet MC. Radioimmunodetection: technical problems and methods of improvement. Eur J Surg Oncol. 1999;25:529–539
  7. Xiao J, Horst S, Hinkle G, et al. Pharmacokinetics and clinical evaluation of 125I-radiolabeled humanized CC49 monoclonal antibody (HuCC49deltaC(H)2) in recurrent and metastatic colorectal cancer patients. Cancer Biother Radiopharm. 2005;20:16–26
  8. Borjesson PK, Postema EJ, de Bree R, et al. Radioimmunodetection and radioimmunotherapy of head and neck cancer. Oral Oncol. 2004;40:761–772
  9. Thor A, Ohuchi N, Szpak CA, et al. Distribution of oncofetal antigen tumor-associated glycoprotein-72 defined by monoclonal antibody B72.3. Cancer Res. 1986;46:3118–3124
  10. Divgi CR, Scott AM, McDermott K, et al. Clinical comparison of radiolocalization of two monoclonal antibodies (mAbs) against the TAG-72 antigen. Nucl Med Biol. 1994;21:9–15
  11. Moffat FL, Pinsky CM, Hammershaimb L, et al. The Immunomedics Study Group Clinical utility of external immunoscintigraphy with the IMMU-4 technetium-99m Fab’ antibody fragment in patients undergoing surgery for carcinoma of the colon and rectum: results of a pivotal, phase III trial. J Clin Oncol. 1996;14:2295–2305
  12. Roselli M, Buonomo O, Piazza A, et al. Novel clinical approaches in monoclonal antibody-based management in colorectal cancer patients: radioimmunoguided surgery and antigen augmentation. Semin Surg Oncol. 1998;15:254–262
  13. Thurston MO. Development of the gamma-detecting probe for radioimmunoguided surgery. In:  Martin EW editors. Radioimmunoguided Surgery (RIGS) in the Detection and Treatment of Colorectal Cancer. Austin, TX: R.G. Landes Company; 1994;
  14. Maurer AH, Urbain J-LC, Malmud LS, et al. Radionuclide imaging: general principles (A Textbook of Medical Imaging). In:  Grainger RG,  Allison DJ,  Adam A, et al. editor. Grainger & Allison’s Diagnostic Radiology. London: Churchill Livingstone; 2001;
  15. Schuster DM, Halkar RK. Molecular imaging in breast cancer. Radiol Clin North Am. 2004;42:885–908vi-vii
  16. Hinkle GH, Laven DL. Radionuclides. In:  Martin EW editors. Radioimmunoguided Surgery (RIGS) in the Detection and Treatment of Colorectal Cancer. Austin, TX: R.G. Landes Company; 1994;
  17. Goldenberg DM, Sharkey RM, Paganelli G, et al. Antibody pretargeting advances cancer radioimmunodetection and radioimmunotherapy. J Clin Oncol. 2006;24:823–834
  18. Hoffman EJ, Tornai MP, Janecek M, et al. Intraoperative probes and imaging probes. Eur J Nucl Med. 1999;26:913–935
  19. Schneebaum S, Even-Sapir E, Cohen M, et al. Clinical applications of gamma-detection probes: radioguided surgery. Eur J Nucl Med. 1999;26:S26–S35
  20. Martin EW, Barnes JA, Thurston MO. Introduction: the RIGS concept. In:  Martin EW editors. Radioimmunoguided Surgery (RIGS) in the Detection and Treatment of Colorectal Cancer. Austin, TX: R.G. Landes Company; 1994;
  21. Aitken DR, Hinkle GH, Thurston MO, et al. A gamma-detecting probe for radioimmune detection of CEA-producing tumors (Successful experimental use and clinical case report). Dis Colon Rectum. 1984;27:279–282
  22. Martin DT, Hinkle GH, Tuttle S, et al. Intraoperative radioimmunodetection of colorectal tumor with a hand-held radiation detector. Am J Surg. 1985;150:672–675
  23. Martinez DA, Barbera-Guillem E, LaValle GJ, et al. Radioimmunoguided surgery for gastrointestinal malignancies: an analysis of 14 years of clinical experience. Cancer Control. 1997;4:505–516
  24. Arnold MW, Schneebaum S, Martin EW. Radioimmunoguided surgery in the treatment and evaluation of rectal cancer patients. Cancer Control. 1996;3:42–45
  25. Nag S, Martinez-Monge R, Nieroda C, et al. Radioimmunoguided-intraoperative radiation therapy in colorectal carcinoma: a new technique to precisely define the clinical target volume. Int J Radiat Oncol Biol Phys. 1999;44:133–137
  26. Arnold MW, Young DM, Hitchcock CL, et al. Staging of colorectal cancer: biology vs. morphology. Dis Colon Rectum. 1998;41:1482–1487
  27. Cohen AM, Martin EW, Lavery I, et al. Radioimmunoguided surgery using iodine 125 B72.3 in patients with colorectal cancer. Arch Surg. 1991;126:349–352
  28. Arnold MW, Schneebaum S, Berens A, et al. Radioimmunoguided surgery challenges traditional decision making in patients with primary colorectal cancer. Surgery. 1992;112:624–629discussion 629-30
  29. Filez L, Penninckx F, Ectors N, et al. Radioimmunoguided surgery for colorectal carcinoma. Hepatogastroenterology. 1999;46:691–700
  30. Schneebaum S, Troitsa A, Haddad R, et al. Immunoguided lymph node dissection in colorectal cancer: a new challenge?. World J Surg. 2001;25:1495–1498discussion 1499
  31. Cote RJ, Houchens DP, Hitchcock CL, et al. Intraoperative detection of occult colon cancer micrometastases using 125 I-radiolabled monoclonal antibody CC49. Cancer. 1996;77:613–620
  32. Schneebaum S, Arnold MW, Houchens DP, et al. The significance of intraoperative periportal lymph node metastasis identification in patients with colorectal carcinoma. Cancer. 1995;75:2809–2817
  33. Martin EW, Carey LC. Second-look surgery for colorectal cancer (The second time around). Ann Surg. 1991;214:321–325discussion 326-7
  34. Bertsch DJ, Burak WE, Young DC, et al. Radioimmunoguided surgery for colorectal cancer. Ann Surg Oncol. 1996;3:310–316
  35. Bertsch DJ, Burak WE, Young DC, et al. Radioimmunoguided Surgery system improves survival for patients with recurrent colorectal cancer. Surgery. 1995;118:634–638discussion 638-9
  36. Kalofonos HP, Karamouzis MV, Epenetos AA. Radioimmunoscintigraphy in patients with ovarian cancer. Acta Oncol. 2001;40:549–557
  37. DeNardo SJ. Radioimmunodetection and therapy of breast cancer. Semin Nucl Med. 2005;35:143–151
  38. Percivale P, Bertoglio S, Meszaros P, et al. Radioimmunoguided surgery after primary treatment of locally advanced breast cancer. J Clin Oncol. 1996;14:1599–1603
  39. Kim JC, Hong HK, Roh SA, et al. Efficient targeting of gastric cancer cells using radiolabeled anti-carcinoembryonic antigen-specific T84.66 fragments in experimental radioimmunoguided surgery. Anticancer Res. 2004;24:663–670
  40. Ellis RJ, Kim EY, Conant R, et al. Radioimmunoguided imaging of prostate cancer foci with histopathological correlation. Int J Radiat Oncol Biol Phys. 2001;49:1281–1286
  41. Agnese DM, Abdessalam SF, Burak WE, et al. Pilot study using a humanized CC49 monoclonal antibody (HuCC49DeltaCH2) to localize recurrent colorectal carcinoma. Ann Surg Oncol. 2004;11:197–202
  42. Arnold MW, Schneebaum S, Berens A, et al. Intraoperative detection of colorectal cancer with radioimmunoguided surgery and CC49, a second-generation monoclonal antibody. Ann Surg. 1992;216:627–632
  43. Avital S, Haddad R, Troitsa A, et al. Radioimmunoguided surgery for recurrent colorectal cancer manifested by isolated CEA elevation. Cancer. 2000;89:1692–1698
  44. Bertoglio S, Benevento A, Percivale P, et al. Radioimmunoguided surgery benefits in carcinoembryonic antigen-directed second-look surgery in the asymptomatic patient after curative resection of colorectal cancer. Semin Surg Oncol. 1998;15:263–267
  45. Burak WE, Schneebaum S, Kim JA, et al. Pilot study evaluating the intraoperative localization of radiolabeled monoclonal antibody CC83 in patients with metastatic colorectal carcinoma. Surgery. 1995;118:103–108
  46. Gu J, Zhao J, Li Z, et al. Clinical application of radioimmunoguided surgery in colorectal cancer using 125I-labeled carcinoembryonic antigen-specific monoclonal antibody submucosally. Dis Colon Rectum. 2003;46:1659–1666
  47. Haddad R, Avital S, Troitsa A, et al. Benefits of radioimmunoguided surgery for pelvic recurrence. Eur J Surg Oncol. 2001;27:298–301
  48. Hladik P, Vizda J, Bedrna J, et al. Immunoscintigraphy and intra-operative radioimmunodetection in the treatment of colorectal carcinoma. Colorectal Dis. 2001;3:380–386
  49. Lechner P, Lind P, Snyder M, et al. Probe-guided surgery for colorectal cancer. Recent Results Cancer Res. 2000;157:273–280
  50. Percivale P, Bertoglio S, Meszaros P, et al. Radioimmunoguided surgery with different iodine-125 radiolabeled monoclonal antibodies in recurrent colorectal cancer. Semin Surg Oncol. 1998;15:231–234
  51. Renda A, Iovino F, Capasso L, et al. Radioimmunoguided surgery in colorectal cancer: a 6-year experience with four different technical solutions. Semin Surg Oncol. 1998;15:226–230
  52. Sickle-Santanello BJ, O’Dwyer PJ, Mojzisik C, et al. Radioimmunoguided surgery using the monoclonal antibody B72.3 in colorectal tumors. Dis Colon Rectum. 1987;30:761–764
  53. Badellino F, Bertoglio S, Mariani G, et al. Use of radioimmunoguided surgery after induction chemotherapy in locally advanced breast cancer. Semin Surg Oncol. 1998;15:245–248
  54. Burak WE, DePalatis L, Mosic JL, et al. Radioimmunoguided breast surgery using radiolabeled antibody NR-LU-10 FAB: a pilot study. Tumori. 2001;87:142–146
  55. Nieroda CA, Mojzisik C, Sardi A, et al. Staging of carcinoma of the breast using a hand-held gamma detecting probe and monoclonal antibody B72.3. Surg Gynecol Obstet. 1989;169:35–40
  56. Bell J, Mojzisik C, Hinkle G, et al. Intraoperative radioimmunodetection of ovarian cancer using monoclonal antibody B72.3 and a portable gamma-detecting probe. Obstet Gynecol. 1990;76:607–611
  57. Ind TE, Granowska M, Britton KE, et al. Peroperative radioimmunodetection of ovarian carcinoma using a hand-held gamma detection probe. Br J Cancer. 1994;70:1263–1266
  58. Lucisano E, Bertoglio S. Role of radioimmunoguided surgery using iodine-125-labeled B72.3 monoclonal antibody in gastric cancer surgery. Semin Surg Oncol. 1998;15:212–214
  59. Mussa A, Sandrucci S, Mobiglia A, et al. Role of radioimmunolocalization in the staging of gastric carcinoma. Semin Surg Oncol. 1998;15:209–211
  60. LaValle GJ, Martinez DA, Sobel D, et al. Assessment of disseminated pancreatic cancer: a comparison of traditional exploratory laparotomy and radioimmunoguided surgery. Surgery. 1997;122:867–871discussion 871-3
  61. Grazia M, Bini A, Stella F, et al. Radioimmunoguided surgery and intraoperative lung cancer staging. Semin Surg Oncol. 1998;15:215–219
  62. Badalament RA, Burgers JK, Petty LR, et al. Radioimmunoguided radical prostatectomy and lymphadenectomy. Cancer. 1993;71:2268–2275

PII: S1055-8586(06)00053-9

doi: 10.1053/j.sempedsurg.2006.07.005

Seminars in Pediatric Surgery
Volume 15, Issue 4 , Pages 259-266 , November 2006

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