Pediatric renal transplantation with considerations for successful outcomes

Renal transplantation in the pediatric population, although conceptually similar to that in adults, differs in many aspects. This review will focus on the issues unique to the pediatric recipient. In particular, we will focus on the incidence and etiology of end stage renal disease in children, and the results as measured by patient and graft survival. Pretransplant surgical considerations of timing of the transplant, management of congenital urologic abnormalies and the abnormal bladder will be addressed. Etiologies of renal failure unique to the pediatric population will be discussed, including autosomal recessive polycystic kidney disease, congenital nephrotic syndrome, inferior vena cava thrombosis, and primary hyperoxaluria Type 1. Lastly, special transplant surgical considerations including transplantation of an adult-size kidney (ASK) into an infant or small child and ureteral implantation, management of the urinary bladder, and fluid management in infants and small children will be discussed.

Index words:  Renal transplantation in children , Chronic renal insufficiency , Renal failure , Congenital urologic anomalies , Nephrotic syndrome , Polycystic kidney disease