Seminars in Pediatric Surgery
Volume 15, Issue 2 , Pages 124-132 , May 2006

Cervicofacial vascular anomalies. I. Hemangiomas and other benign vascular tumors

  • Denise M. Adams, MD

      Affiliations

    • Division of Hematology/Oncology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio
    • Hemangioma and Vascular Malformation Center, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio
    • Corresponding Author InformationAddress reprint requests and correspondence: Denise Adams, MD, Division of Hematology/Oncology, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH 45229
  • ,
  • Anne W. Lucky, MD

      Affiliations

    • Division of Pediatric Dermatology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio

References 

  1. Mulliken JB , Glowacki J . Hemangiomas and vascular malformations in infants and children (a classification based on endothelial characteristics) . Plast Reconstr Surg . 1982;69:412–422
  2. Mulliken JB , Enjoras O . Congenital hemangiomas and infantile hemangioma (missing links) . J Am Acad Dermatol . 2004;50:875–882
  3. Leon-Villapalos J , Wolfe K , Kangesu L . GLUT -1 (an extra diagnostic tool to differentiate between hemangiomas and vascular malformations) . Br J Plast Surg . 2005;58:348–352
  4. North PE , Waner M , Mizeracki AM , et al.   A unique microvascular phenotype shared by juvenile and human placenta . Arch Dermatol . 2001;137:559–570
  5. Fishman SJ , Mulliken JB . Vascular anomalies (a primer for pediatricians) . Pediatr Clin North Am . 1998;45:1455–1477
  6. Enjolras O , Mulliken JB . Vascular tumors and vascular malformations (new issues) . Adv Dermatol . 1997;13:375–423
  7. Drolet B , Esterly N , Frieden IJ . Hemangiomas in children . N Engl J Med . 1999;341:173–181
  8. Cohen RC , Myers NA . Diagnosis and management of massive hepatic hemangiomas in childhood . J Pediatr Surg . 1986;21:6–9
  9. Enjolras O , Riche MC , Merland JJ , et al.   Management of alarming hemangiomas in infancy (a review of 25 cases) . Pediatrics . 1990;85:491–498
  10. Berenguer B , Mulliken JB , Enjolras O , et al.   Rapidly involuting congenital hemangioma (clinical and histopathologic features) . Pediatr Developmental Pathol . 2003;6:495–510
  11. Frieden IJ , Reese V , Cohen D . PHACE syndrome (The association of posterior fossa brain malformations, hemangiomas, arterial anomalies, coarctation of the aorta and cardiac defects, and eye abnormalities) . Arch Dermatol . 1996;132:307–311
  12. Reese V , Frieden IJ , Paller AS , et al.   Association of facial hemangiomas with Dandy-Walker and other posterior fossa malformations . J Pediatr . 1993;122:379–384
  13. Burrows PE , Robertson RL , Mulliken JB , et al.   Cerebral vasculopathy and neurologic sequelae in infants with cervicofacial hemangioma (report of eight patients) . Radiology . 1998;207:601–607
  14. Orlow SJ , Isakoff MS , Blei F . Increased risk of symptomatic hemangiomas of the airway in association with cutaneous hemangiomas in a “beard” distribution . J Pediatr . 1997;131:643–646
  15. Kushner B . Infantile orbital hemangiomas . Int Pediatr . 1990;5:249–257
  16. Cruz OA , Zarnegar SR , Myers SE . Treatment of periocular capillary hemangioma with topical clobetasol propionate . Ophthalmology . 1995;102:2012–2015
  17. Bartoshesky LE , Bull M , Feingold M . Corticosteroid treatment of cutaneous hemangiomas (how effective? A report on 24 children) . Clin Pediatr (Phila) . 1978;17:625; 629-38.
  18. Brown SH , Neerhout RC , Fonkalsrud EW . Prednisone therapy in the management of large hemangiomas in infants and children . Surgery . 1972;71:168–173
  19. Hasan Q , Tan ST , Gush J , et al.   Steroid therapy of a proliferating hemangioma (histochemical and molecular changes) . Pediatrics . 2000;105:117–120
  20. Boon LM , MacDonald DM , Mulliken JB . Complications of systemic corticosteroid therapy for problematic hemangioma . Plast Reconstr Surg . 1999;104:1616–1623
  21. Enjolras O , Breviere GM , Roger G , et al.   Vincristine treatment for function- and life-threatening infantile hemangioma . Arch Pediatr . 2004;11:99–107
  22. Adams DM, Orme L, Bowers D. Vincristine treatment of complicated hemangiomas. 14th International Workshop on Vascular Anomalies, Netherlands, June 2002
  23. Ezekowitz RA , Mulliken JB , Folkman J . Interferon alfa-2a therapy for life-threatening hemangiomas of infancy . N Engl J Med . 1992;326:1456–1463
  24. Chang E , Boyd A , Nelson CC , et al.   Successful treatment of infantile hemangiomas with interferon-alpha-2b . J Pediatr Hematol Oncol . 1997;19:237–244
  25. Barlow CF , Priebe CJ , Mulliken JB , et al.   Spastic diplegia as a complication of interferon Alfa-2a treatment of hemangiomas of infancy . J Pediatr . 1998;132:527–530
  26. Batta K , Goodyear HM , Moss C , et al.   Randomised controlled study of early pulsed dye laser treatment of uncomplicated childhood haemangiomas (results of a 1-year analysis) . Lancet . 2002;360:521–527
  27. Mulliken JB , Rogers GF , Marler JJ . Circular excision of hemangioma and purse-string closure (the smallest possible scar) . Plast Reconstr Surg . 2002;109:1544–1554
  28. Hazen PG , Carney JF , Engstrom CW , et al.   Proliferating hemangioma of infancy (successful treatment with topical 5% imiquimod cream) . Pediatr Dermatol . 2005;22:254–256
  29. Metz BJ , Rubenstein MC , Levy ML , et al.   Response of ulcerated perineal hemangiomas of infancy to becaplermin gel, a recombinant human platelet-derived growth factor . Arch Dermatol . 2004;140:867–870
  30. Kasabach H , Merritt K . Capillary hemangioma with extensive purpura (report of a case) . Am J Dis Child . 1940;59:1063–1070
  31. Haisley-Royster C , Enjolras O , Frieden IJ , et al.   Kasabach-merritt phenomenon (a retrospective study of treatment with vincristine) . J Pediatr Hematol Oncol . 2002;24:459–462
  32. Sarkar M , Mulliken JB , Kozakewich HP , et al.   Thrombocytopenic coagulopathy (Kasabach-Merritt phenomenon) is associated with Kaposiform hemangioendothelioma and not with common infantile hemangioma . Plast Reconstr Surg . 1997;100:1377–1386
  33. Enjolras O , Wassef M , Mazoyer E , et al.   Infants with Kasabach-Merritt syndrome do not have “true” hemangiomas . J Pediatr . 1997;130:631–640

PII: S1055-8586(06)00022-9

doi: 10.1053/j.sempedsurg.2006.02.010

Seminars in Pediatric Surgery
Volume 15, Issue 2 , Pages 124-132 , May 2006