Seminars in Pediatric Surgery
Volume 14, Issue 3 , Pages 145-151, August 2005

The role of PAF, TLR, and the inflammatory response in neonatal necrotizing enterocolitis

  • Michael S. Caplan, MD

      Affiliations

    • Corresponding Author InformationAddress reprint requests and correspondence: Michael S. Caplan, MD, Department of Pediatrics, Evanston Northwestern Healthcare, 2650 Ridge Avenue, Evanston, IL 60201
    • ,
  • Dyan Simon, MD
    • ,
  • Tamas Jilling, MD

Department of Pediatrics, Evanston Northwestern Healthcare and The Evanston Northwestern Healthcare Research Institute, Northwestern University, Feinberg School of Medicine, Evanston, Illinois

The pathogenesis of neonatal necrotizing enterocolitis remains poorly understood. Recent evidence suggests that PAF (platelet activating factor) and human toll-like receptors (TLRs) contribute to the pro-inflammatory response that is characteristic of NEC pathology. Understanding the regulation of these molecular interactions may provide new approaches for prevention or treatment of this dreaded condition.

Index words:  Neonatal necrotizing enterocolitis, NEC , Platelet activating factor, PAF , Bacteria , Human toll-like receptor, TLR

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PII: S1055-8586(05)00030-2

doi:10.1053/j.sempedsurg.2005.05.002

Seminars in Pediatric Surgery
Volume 14, Issue 3 , Pages 145-151, August 2005

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