Seminars in Pediatric Surgery
Volume 14, Issue 3 , Pages 137-144, August 2005

Intestinal innate immunity: How does it relate to the pathogenesis of necrotizing enterocolitis

  • Josef Neu, MD

      Affiliations

    • Department of Pediatrics, University of Florida College of Medicine, Gainesville, Florida
    • ,
  • Mike Chen, MD

      Affiliations

    • Department of Surgery, University of Florida College of Medicine, Gainesville, Florida
    • ,
  • Elizabeth Beierle, MD

      Affiliations

    • Department of Surgery, University of Florida College of Medicine, Gainesville, Florida
    • Corresponding Author InformationAddress reprint requests and correspondence: Elizabeth A. Beierle, MD, University of Florida College of Medicine, Division of Pediatric Surgery, 1600 SW Archer Road, Room N6-10, Gainesville, FL 32608

The pathogenesis of necrotizing enterocolitis (NEC) is poorly understood, but appears to be multifactorial and highly associated with immaturity of the gastrointestinal tract, colonization of the intestinal microbiota, and immature innate immune system. The goal of this review is to provide an overview of some of these risk factors and how they might lead to the genesis of NEC. A better understanding of these factors should help us prevent and treat this devastating disease.

Index words:  NEC , Prematurity , Inflammation , Immunity , Intestine , Nutrition

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PII: S1055-8586(05)00029-6

doi:10.1053/j.sempedsurg.2005.05.001

Seminars in Pediatric Surgery
Volume 14, Issue 3 , Pages 137-144, August 2005

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